Research Scientist - Dr. Amantha Thathiah's Laboratory

Med-Neurobiology - Pennsylvania-Pittsburgh - (25005733)

We are seeking a Research Scientist to join Amantha Thathiah's lab in the Department of Neurobiology. The focus of the research in the Thathiah lab is to study the cellular and molecular mechanisms involved in the pathogenesis of Alzheimers disease (AD). Neuropathologically, the brains of AD patients are characterized by the accumulation of aggregates of the amyloid- (A) peptide and neurofibrillary tangles, which are composed of the hyperphosphorylated microtubule-associated protein tau. The Thathiah lab investigates the involvement of G protein-coupled receptors (GPCRs) in modulation A and tau pathology and the cross-talk between A and tau in disease progression. We combine cellular and biochemical techniques with mouse models of neurodegeneration and behavioral studies to address our research questions.

Job Summary

Conducts independent scientific research projects from inception to presentation. Prepares and crafts various documentations of research results into manuscripts, proposals, grant applications, and presentations. Trains undergraduates and research technicians. Manages laboratory policies and coordinates project development in collaboration with other specialists.

Essential Functions

The Thathiah Laboratory at the University of Pittsburgh School of Medicine is seeking a highly motivated and skilled scientist to lead a newly established NIH-funded Cellular Modeling Core (CMC). The CMC Lead will oversee the generation, maintenance, and characterization of cellular models, derived from both human and non-human primate fibroblasts, to support Alzheimer’s Disease research. This position involves working with marmoset-derived cell lines, optimizing reprogramming techniques, and developing in vitro models to study disease mechanisms. The ideal candidate will have expertise in cell culture, cellular reprogramming techniques (i.e., iPSC and direct conversion), molecular biology and biochemical techniques, and will play a key role in advancing translational research within a collaborative, cutting-edge scientific environment.

Physical Effort

Wet lab bench work, which involves sitting/standing/moving around.

Assignment Category: Full-time regular

Job Classification: Staff.Research Scientist

Job Family: Research

Job Sub Family: Research Science

Campus: Pittsburgh

Minimum Education Level Required: Professional Doctorate Degree

Minimum Years of Experience Required: 5

Will this position accept substitution in lieu of education or experience: Combination of education and relevant experience will be considered in lieu of education and/ or experience requirement.

Work Schedule: Monday - Friday, 9:00 a.m. - 5:00 p.m., with occasional weekend hours

Work Arrangement: On-Campus: Teams that work on campus, in an office, or in a lab.

Hiring Range: TBD Based Upon Qualifications

Relocation_Offered: Yes

Visa Sponsorship Provided: Yes

Background Check: For position finalists, employment with the University will require successful completion of a background check

Child Protection Clearances: Not Applicable

Required Documents: Resume, Cover Letter

Optional Documents: Not Applicable