About C4 Therapeutics:

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com.

About Cemsidomide:

Cemsidomide is an investigational, orally bioavailable small-molecule degrader designed to be a more potent and selective degrader of IKZF1/3, transcription factors that drive multiple myeloma (MM), with unique pharmacokinetic properties. Data from the Phase 1 trial demonstrate cemsidomide’s favorable safety and tolerability profile and class-leading anti-myeloma activity, supporting clear development paths for second line and later patient populations. C4T plans to advance cemsidomide through two clinical trials that will position the medicine for two distinct potential accelerated approvals.

Job Summary:

In this role, reporting to the President & Chief Executive Officer, you will bring together the various functions involved in advancing Cemsidomide through registrational development and FDA approval to define, lead, and drive the execution of our plan to ensure a successful commercial product. Your combination of drug development, commercialization and launch expertise, strategic thinking, and collaborative leadership will be key as you oversee the execution of a strategy that will be enthusiastically received by global regulators and potential patient populations.

Your experience in guiding clinical-stage hematological oncology assets into registrational development and commercialization will help you build strong partnerships across functions and with external collaborators. You will work to develop shared understanding across perspectives, align the team on program goals, and create conditions for successful execution. This role offers meaningful visibility across the organization, including closely partnering with the Senior Leadership Team, and the opportunity to make a lasting, positive impact on patients globally as part of C4T’s mission.

Your Role:

• Lead the intersection of scientific, commercial and business aspects of the Cemsidomide program, including designing and delivering strategic development plans that reflect patient and commercial insights, defining milestones and key deliverables for needs across development and lifecycle management, ensuring that strategies are informed by evidence, clinical insights, and the evolving commercial and patient landscape.
• Represent the program internally and externally, building relationships with groups that will be pivotal to commercial success and highlight the potential future of the asset (i.e. patient advocacy groups, key medical experts, policy makers, payors etc.); contribute to business development activities such as evaluating in-licensing or out-licensing opportunities.
• In collaboration with Program Manager, develop, implement, and maintain integrated project management plans covering program scope, timelines, budget, communications, risks, staffing, and change management — partnering with Finance, HR, and other functions as needed.
• Anticipate challenges early, develop thoughtful solutions, and ensure contingency plans are in place.
• Facilitate cross-functional team meetings, fostering a constructive environment, encouraging open discussion, and ensuring decisions and action items are addressed to completion.
• Promote open and transparent communication of program goals, progress, and challenges with stakeholders including the program team, senior leadership, board members, alliance partners, collaborators, regulatory agencies, and others as needed.

Your Background:

• Bachelor’s Degree, with at least twelve years of experience in biotechnology or pharmaceutical development, including a strong record in both late-stage and commercial program leadership for hematological oncology products.
• An understanding of the scientific principles behind C4T’s research and development, as well as broad knowledge of the biotechnology market, regulatory landscape, drug development process, global product registration, market dynamics, launch and pricing strategies, and business development.
• A collaborative leader who can build rapport and authority by leveraging strong interpersonal skills to figure out barriers to engagement and build healthier teams; comfort with seeking out internal or external experts to understand roadblocks, using this knowledge to build deeper relationships, and build consensus on best path forward for the program.
• Proven matrix leadership skills with a comfort shifting easily between strategic thinking and practical execution to resolve conflicts and build consensus with individuals of varied disciplines and levels, both internal and external.
• Skilled in communicating with clarity across audiences and levels in writing, verbally, and through presentations — providing the right context, listening actively, and working toward shared understanding.

C4 Therapeutics is an Equal Opportunity Employer.