Postdoctoral Fellow – Bone Metastatic Cancer Biology

A fully funded postdoctoral position is available in the laboratory of Dr. Conor C. Lynch within the Department of Tumor Microenvironment & Metastasis at Moffitt Cancer Center. The Lynch laboratory studies the molecular and cellular mechanisms that drive tumor progression and metastasis within the bone microenvironment, with a particular focus on bone metastatic prostate cancer, multiple myeloma, and osteosarcoma.

Research in the laboratory integrates tumor biology, bone biology, and immunology to understand how cancer cells interact with the bone niche and how these interactions promote tumor growth, therapy resistance, and disease progression. The laboratory has a strong translational focus, including the development and testing of novel small molecule inhibitors and therapeutic strategies targeting the tumor–bone microenvironment.

Position Highlights

• Projects include investigating novel therapeutic strategies and small molecule inhibitors targeting tumor progression in bone metastatic prostate cancer, multiple myeloma, and osteosarcoma.
• Research focuses on mechanistic studies of tumor–bone and tumor–immune microenvironment interactions, including how these interactions regulate metastasis, tumor dormancy, and therapeutic resistance.
• Opportunities exist to apply cutting-edge molecular and genomic approaches, including spatial transcriptomics, single-cell RNA sequencing, and multi-omic analyses, to study tumor–bone interactions.
• Moffitt integrates outstanding clinical care with cutting-edge basic and translational research, providing unique opportunities to collaborate with physician-scientists and access patient-derived samples.
• Outstanding mentorship in a collaborative and highly interactive research environment with strong opportunities to develop independent research programs and competitive fellowship applications.
• Access to state-of-the-art core facilities including genomics, spatial biology platforms, bioinformatics, imaging, and animal models.

The Ideal Candidate

• The successful candidate will be a motivated scientist interested in the tumor bone microenvironment and metastasis.

• Highly motivated and independent
• Strong written and verbal communication skills
• Ability to work collaboratively in an interdisciplinary research environment
• Willingness to write fellowship applications and manuscripts
• Experience with cell culture, molecular biology, protein/DNA techniques, supported by peer-reviewed publications
• Experience with in vivo models and histology is preferred
• Experience or familiarity with spatial transcriptomics, single-cell RNA sequencing, and genomic data analysis is highly desirable
• Experience with coding languages (e.g., R, Python) or bioinformatics approaches is a plus but not required

Responsibilities

• Develop and execute independent research projects related to tumor–bone microenvironment interactions
• Design and perform molecular, cellular, and in vivo experiments
• Analyze and interpret experimental data
• Assist with manuscript and grant preparation
• Train and mentor students or junior laboratory personnel
• Maintain accurate and detailed research records
• Present research findings at lab meetings and national/international conferences

Credentials and Qualifications

• PhD, MD, or MD/PhD in cancer biology, molecular biology, cell biology, immunology, or a related field
• At least one first-author peer-reviewed publication
• Experience in cancer biology, bone biology, metastasis, or tumor microenvironment research is strongly preferred

How to Apply

Interested applicants should submit a single PDF file including:

• Cover letter describing research interests and career goals
• Curriculum vitae including publication list
• Contact information for three references

Moffitt Postdocs are provided with Medical Insurance (Moffitt covers premium for team members) effective upon start date and eligible for Dental, Vision, Paid Time Off, Retirement, Parental Leave and more. You may be eligible for relocation assistance per policy. Reasons to relocate, aside from the sunshine, beaches and year-round outdoor recreation associated with the Gulf Coast of Florida, Tampa is a thriving metropolitan city, which has become a hub for ground-breaking research, welcoming individuals from around the globe. This diverse city is engulfed with rich culture, year-round activities for all, beautiful beaches, amazing cuisine and so much more. We strive for work/life balance.

If you have the vision, passion, and dedication to contribute to our mission,

then we have a place for you.