About C4 Therapeutics:

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com.

Job Summary

C4 Therapeutics is seeking a highly motivated and innovative Principal Scientist in Immunology to lead discovery and translational research for autoimmune and inflammatory diseases within our targeted protein degradation (TPD) platform.

In this role, you will drive mechanism-based therapeutic strategies, advancing degrader programs from target identification through IND-enabling studies, with a strong emphasis on human biology, immune modulation, and translational relevance. You will operate at the intersection of immunology, chemical biology, and drug discovery, contributing to a high-impact pipeline addressing significant unmet needs in inflammatory and autoimmune diseases. You will use your strong critical-thinking skills to independently design, execute, troubleshoot, and analyze experiments in our exciting fast-paced environment. Your deep expertise and scientific curiosity will be key as you are asked to contribute meaningfully to your projects, propose and explore new ideas, and adapt and pivot to follow the latest cutting-edge innovations in the immunology field.

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Compensation

The base pay range for this position at commencement of employment is expected to be between $187,632.00 and $207,383.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.

C4 Therapeutics is an Equal Opportunity Employer.