Senior Molecular Technologist (Molecular Technologist III) in Waltham, Massachusetts at MaxCyte, Inc

MaxCyte SeQure platform is applying state of the art genomics technologies for CRISPR gene editor target profiling to advance discovery, clinical development, and diagnostic solutions. Our technologies provide the foundation needed to ensure that these life-saving therapies will be both safe and effective. This is an excellent opportunity to engage with established leaders in the field and become part of a dynamic team with substantial opportunities for growth and career development. MaxCyte offers a competitive compensation and benefits package and is an Equal Opportunity Employer.

We are seeking a Senior Molecular Technologist (Molecular Technologist III) to join our Laboratory Operations team to perform novel NGS based assays for the assessment of on- and off-target edits generated by gene editing technologies for cell and gene therapy applications. The ideal candidate will have extensive experience performing high-complexity molecular testing in a regulated laboratory environment, including automated NGS workflows, sequencing, quality control, equipment management, and technical troubleshooting. This individual will serve as a technical resource within Laboratory Operations, support the implementation and transfer of new assays, train junior personnel, and drive continuous improvement initiatives while remaining primarily hands-on at the bench.

Job Responsibilities:

• Perform complex molecular biology and NGS workflows, including sample preparation, nucleic acid processing, PCR, library preparation, library purification, quality control, sequencing, and other downstream processing activities.
• Execute testing in accordance with approved Standard Operating Procedures, study-specific instructions, development protocols.
• Operate and maintain automated liquid handling platforms, NGS sequencers, and other molecular laboratory equipment, including pipettes, thermocyclers, centrifuges, fluorometers, and fragment analysis instruments.
• Lead or troubleshoot assay failures, equipment malfunctions, automation errors, and unexpected quality control results.
• Support assay, instrument, and automation validation activities, including equipment qualification, technology transfer, verification, and implementation.
• Manage multiple concurrent workflows while maintaining accuracy, documentation quality, and turnaround time commitments.
• Lead or substantially contribute to investigations of deviations, nonconformances, incidents, assay failures, and other quality events, including root cause analysis and corrective and preventive actions.
• Author, review, revise, and implement SOPs, work instructions, forms, training materials, validation documents, and other controlled quality records.
• Support laboratory inventory management, reagent qualification, vendor evaluation, material forecasting, and implementation of alternative supplies or vendors.

• Bachelor’s degree in clinical laboratory science, medical technology, molecular biology, biochemistry, genetics, chemical or biological sciences, or a related discipline.
• 5+ years of relevant molecular laboratory experience, including experience in a regulated, clinical, GLP, GMP, ISO or similarly controlled laboratory environment.
• Demonstrated experience with automated NGS workflows, laboratory documentation, and quality systems in a regulated environment.
• Demonstrated ability to independently troubleshoot complex molecular workflows and drive laboratory process improvements. Demonstrated ability to manage multiple laboratory activities while maintaining accuracy, quality, and turnaround-time commitments.
• Excellent written and verbal communication skills.

Preferred Qualifications

• Experience with CRISPR gene editing, off-target analysis, or cell and gene therapy applications.
• Experience with hybrid capture, targeted enrichment, high-throughput sequencing, or complex multiplexed library preparation.
• Experience with amplicon-based sequencing, targeted amplicon panel workflows, or similar targeted NGS applications, including library preparation, amplification, pooling, quality control, and sequencing.
• Master’s degree in molecular biology, genomics, bioinformatics, biotechnology, or a related scientific discipline or ASCP certification in molecular biology or another relevant laboratory certification.

Work Environment & Logistics

• Full-time, exempt position
• 100% on-site in Waltham, Massachusetts
• Standard work schedule Monday through Friday
• No travel required

MaxCyte offers a base salary, annual bonus, and equity. MaxCyte also offers a comprehensive benefits package including health, dental, vision, life, and disability insurance and generous time off.

MaxCyte is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status