RESEARCH ASSOCIATE III at H. Lee Moffitt Cancer Center – Tampa, Florida

A main problem in the treatment of advanced cancers is the incertitude at which we predict how individual patients will respond to therapeutic agents, especially on the long run. Despite a wealth of genomic information, “more-is-better” and “one-size-fits-all” remain the principles according to which cancer drugs are administered.

The lab of Dr. Noemi Andor seeks applications from individuals to test the potential of the long-term legacy DNA-damage entails on a cell -genomic instability and aneuploidy - as new biomarkers of therapeutic response and selection by the tumor microenvironment .

H. Lee Moffitt Cancer and Research Institute is an NCI-Designated Comprehensive Cancer Center in Tampa, Florida. We strive to be the leader in understanding the complexity of cancer through team science and applying those insights for human benefits. Be part of the cure by joining Moffitt's team of over 800 research faculty scientists, career staff scientists, postdocs, graduate students, and support staff dedicated to cancer research.

Position Highlights:

• This scientist will be part of a multi-disciplinary team in the Department of Integrated Mathematical Oncology (IMO), where wet- and dry-lab components are integrated to predict the long-term evolution of heterogeneous cell populations.
• This position brings a unique opportunity to work at the forefront of this multidisciplinary field, in an environment where experimental and computational domains intertwine.

The Ideal Candidate:

• Has extensive experience working with cell lines, optimizing their growth conditions and exposing them to extreme conditions.
• Has worked with a variety of cell viability assays and performed multi-color flow cytometry sorting of cells
• Has hands-on experience using advanced fluorescence microscopy and knowledge on how to acquire quantifiable microscopy data.
• Has expertise in biochemical and genetic assas including western blotting, immunoprecipitation and CRISPR-Cas9 gene editing.
• Has interest in learning basics of programming to trace long-term trends in the clonal evolution of cell populations.

Responsibilities:

• Exposing cell lines to therapeutic agents and quantifying drug-induced changes in their clonal composition from different perspectives, including their transcriptome and morphology.
• Communicating with computer scientists and mathematicians.

Credentials and Qualifications:

• Minimum Bachelor’s degree in related field with 2 years of hands-on research experience is required.
  • Master’s Degree in a related field with 1 year of hands-on research experience is preferred.
• Ability to work independently is required.
• Ability to plan, organize and coordinate work assignments.
• Ability to establish and maintain effective working relationships with others and communicate clearly, verbally and in writing.