Executive Director, Toxicology in New York at Jobgether

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Executive Director, Toxicology based in United States.

This is a senior scientific leadership role responsible for shaping nonclinical safety strategy across discovery and development programs, with a strong focus on small-molecule therapeutics.
You will provide strategic and operational leadership across toxicology and safety pharmacology, supporting target selection, lead optimization, and regulatory milestones.
The role combines deep scientific expertise with cross-functional program leadership across toxicology, DMPK, pathology, pharmacology, and clinical development.
You will represent nonclinical safety at governance forums and in interactions with regulatory authorities, senior leadership, partners, and CROs.
A major focus will be building scalable toxicology capabilities and developing a high-performing team as the therapeutic pipeline grows.
You will guide complex safety assessments and integrated data-driven decisions across multiple stages of drug development.
This opportunity is ideal for an experienced toxicology leader who can combine scientific rigor, regulatory expertise, strategic judgment, and strong people leadership in a fast-paced environment.

• Lead and mentor a team of toxicologists and technical or operational professionals, fostering scientific excellence, collaboration, and professional development.
• Define and execute nonclinical safety strategies across discovery, preclinical, IND-enabling, and clinical development programs.
• Provide expert toxicology and safety pharmacology guidance to cross-functional development teams and support critical program decisions.
• Lead nonclinical sub-teams as an integrated development leader, coordinating activities across Toxicology, DMPK, Bioanalytical Sciences, and Clinical Pharmacology.
• Serve as the primary nonclinical representative on Program Development Teams, internal governance forums, and external scientific or regulatory engagements.
• Champion program strategy and communicate scientific rationale effectively with senior leadership, partners, CROs, and health authorities.
• Design, oversee, and interpret GLP, non-GLP, investigative, and in vitro toxicology studies.
• Develop safety strategies for new targets, lead optimization programs, and emerging platform technologies.
• Oversee internal and outsourced toxicology and safety pharmacology studies, ensuring scientific quality, compliance, and timely delivery.
• Author and critically review toxicology content for regulatory documents, including pre-IND materials, INDs, and Investigator Brochures.
• Partner with Biology, DMPK, Pathology, Pharmacology, Clinical, and Regulatory teams to enable integrated development decisions.
• Present nonclinical safety data, risk assessments, and strategic recommendations to project teams and senior R&D leadership.
• Represent nonclinical safety in regulatory agency interactions and support product defense and regulatory submissions with robust scientific rationale.
• Provide strategic guidance on safety issue resolution and investigational toxicology approaches.
• Contribute to portfolio-level planning, prioritization, and allocation of nonclinical safety resources.
• Build scalable toxicology capabilities that can support a growing and diverse development pipeline.

• PhD in Toxicology, Pharmacology, Pathology, DVM, or a related discipline; board certification such as DABT or ERT is preferred.
• 18+ years of experience in pharmaceutical or biotechnology R&D, with a strong track record in nonclinical and regulatory toxicology.
• Proven ability to operate as an upward-facing nonclinical leader and generalist, with the scientific credibility and judgment to represent development teams in governance settings and engage confidently with regulatory agencies.
• Deep expertise supporting small-molecule programs across discovery, IND-enabling activities, and early clinical development.
• Strong working knowledge of national and international GLP guidelines and regulatory expectations.
• Demonstrated experience defining and executing nonclinical safety strategies across diverse pipelines and novel biological approaches.
• Proven leadership experience building, managing, mentoring, and developing toxicology teams within collaborative, matrixed environments.
• Extensive experience preparing and reviewing nonclinical sections of global regulatory submissions and interacting with health authorities, including the FDA and EMA.
• Strong ability to integrate complex datasets across toxicology, pathology, DMPK, and pharmacology to inform development strategy and decision-making.
• Experience overseeing outsourced toxicology and safety pharmacology studies and managing relationships with CRO partners.
• Excellent communication, presentation, influencing, and stakeholder-management skills, with the ability to work effectively across Early Development, Research, and Regulatory functions.
• Strong strategic judgment, scientific problem-solving abilities, and the ability to make sound decisions in a fast-paced and evolving environment.
• Willingness and ability to travel occasionally as required for the role.

• Anticipated annual compensation of $153,000–$290,400, depending on education, experience, skills, and geographic location.
• Eligibility for a company bonus, based in part on organizational and individual performance.
• 401(k) plan and pension benefits.
• Vacation benefits and certain time-off and leave benefits.
• Eligibility for medical, dental, vision, and prescription drug coverage.
• Flexible benefits, including healthcare and/or dependent day-care flexible spending accounts.
• Life insurance and death benefits.
• Well-being benefits, including an employee assistance program, fitness benefits, and employee clubs and activities.
• Remote work opportunity within the United States.
• Opportunity to lead high-impact nonclinical safety strategy across innovative drug development programs.
• Opportunity to build and develop a high-performing toxicology organization while influencing portfolio-level scientific and development decisions.
• Inclusive workplace committed to equal employment opportunities and reasonable accommodations for qualified individuals with disabilities.