SENIOR HR GENERALIST in SAINT LOUIS, Missouri at BIOSTL INC

Job Title: Senior HR Generalist

Position Summary

BioSTL is seeking a hands-on, experienced Senior HR Generalist to manage and execute the full scope of day-to-day human resources operations. This role is responsible for delivering high-quality, compliant, and employee-centered HR services across the organization, including recruiting, payroll and benefits administration, employee relations, compliance, performance management, and HR systems.

This is a highly operational role ideal for an HR professional who enjoys owning processes end-to-end, partnering closely with leadership, and serving as a trusted resource for employees and managers. The position is primarily on-site, with a regular schedule of, at least, four days per week in the office to support employees and the organization effectively.

Key Responsibilities

HR Operations & Employee Lifecycle

• Manage all aspects of the employee lifecycle, including recruiting, onboarding, orientation, job changes, and offboarding
• Serve as the primary point of contact for employee HR inquiries, providing timely and accurate guidance
• Maintain employee personnel files and HR records in accordance with legal and organizational requirements
• Administer and continuously improve HR policies, procedures, and practices

Recruiting & Talent Acquisition

• Manage the full-cycle recruiting process for all open positions, from workforce planning and job postings through offer creation and onboarding
• Partner with hiring managers to define role requirements, develop job descriptions, and determine effective sourcing strategies
• Post and manage job openings across appropriate platforms and networks
• Screen resumes, conduct initial candidate interviews, coordinate interview logistics, and support hiring teams through selection
• Prepare and extend offers, including compensation coordination, background checks (as applicable), and pre-employment requirements
• Ensure a positive, professional candidate experience throughout the recruiting process
• Maintain recruiting metrics and documentation; identify opportunities to improve efficiency, equity, and quality of hire

Payroll Administration

• Own the end-to-end payroll process, ensuring timely and accurate payroll processing
• Coordinate payroll inputs including new hires, terminations, pay changes, bonuses, and deductions
• Reconcile payroll reports and resolve discrepancies
• Serve as liaison with payroll vendors and internal finance partners
• Ensure compliance with federal, state, and local wage and hour regulations

Benefits & Ancillary Programs

• Administer all employee benefits programs, including medical, dental, vision, life insurance, disability, retirement plans, and other ancillary offerings
• Serve as subject-matter expert for benefits, assisting employees with enrollment, changes, and issue resolution
• Lead annual open enrollment, including planning, communications, vendor coordination, and employee education
• Manage relationships with benefits brokers and vendors
• Ensure compliance with ACA, COBRA, ERISA, and other applicable regulations
• Compliance & Risk Management
• Ensure compliance with federal, state, and local employment laws and regulations
• Monitor and update HR practices to reflect regulatory changes
• Support audits, reporting, and filings related to payroll, benefits, and HR compliance
• Assist with workers’ compensation administration and claims management

Performance Management & Employee Relations

• Support and administer the performance management process, including goal setting, reviews, and documentation
• Coach managers and employees on performance, conduct, and workplace issues
• Assist with employee relations matters, including investigations, corrective action, and conflict resolution
• Promote a positive, inclusive, and respectful workplace culture

HR Systems & Reporting

• Administer HRIS, payroll, benefits, and recruiting systems, ensuring data accuracy and integrity
• Generate routine and ad hoc HR, recruiting, and payroll reports as needed
• Identify opportunities to streamline processes and improve system utilization

Strategic & Organizational Support

• Partner with leadership to align HR practices, recruiting efforts, and workforce planning with organizational goals
• Contribute to HR initiatives such as process improvement, training, and organizational development
• Participate in special projects and organizational initiatives as assigned with contracted support

Qualifications

Required

• Bachelor’s degree in Human Resources, Business Administration, or related field
• Minimum of 5–7 years of progressive HR Generalist experience
• Demonstrated hands-on experience with full-cycle recruiting, payroll processing, and benefits administration
• Strong working knowledge of employment laws and HR compliance requirements
• Experience working with HRIS, payroll, and recruiting systems
• Proven ability to manage multiple priorities with accuracy and attention to detail

Preferred

• HR certification (PHR, SHRM-CP, or higher)
• Experience in a nonprofit, healthcare, life sciences, or mission-driven organization
• Familiarity with multi-state payroll, benefits, and recruiting practices
• Skills & Competencies
• Highly organized and detail-oriented
• Practical, solutions-focused approach to HR and recruiting
• Strong interpersonal and communication skills
• Ability to handle confidential and sensitive information with discretion
• Comfortable operating independently while collaborating closely with leadership
• Trusted advisor to employees, candidates, and managers alike

Work Environment & Schedule

• Full-time, exempt position
• Primarily on-site, at least, four days per week to support employees, candidates, and organizational needs
• Occasional flexibility required to meet recruiting, payroll, benefits, or operational deadlines