E11 Bio - Scientist, Tissue & Imaging Quality at Convergent Research – Alameda, California
Convergent Research
Alameda, California, 94501, United States
Posted on
Updated on
Salary:$96000 - $144000Job Function:Science
Explore Related Opportunities
About This Position
E11 Bio - Scientist, Tissue & Imaging Quality
$96,000 - $144,000 a year
E11 Bio is a Focused Research Organization (FRO) with a long-term mission to make connectomics scalable and cost-effective for mammalian brains first for mice and eventually for humans.
We have recently developed PRISM, a platform technology for low cost optical connectomics. PRISM integrates advances in genetic cell barcoding, multiplexed expansion microscopy, and machine-learning based -based spatial reconstruction to solve key bottlenecks in data acquisition and analysis. PRISM will reduce the cost of connectomics 100-fold and thereby transform neuroscience, treatments for brain disorders, and neuro-inspired computing.
E11 Bio is seeking a mission-aligned experimental scientist who is equally comfortable at the bench, the microscope, and with quantitative data analysis. This role is responsible for sample preparation end-to-end for high-quality connectomics, combining hands-on experimental work with quantitative image-based QC to diagnose failure modes and iteratively improve protocols. You will collaborate closely with molecular biology, imaging, and computational teams to ensure we consistently prepare high quality specimens and brain tissue to support our ambitious scaling goals towards whole-brain connectomics.
Core Responsibilities- Ensure consistent end-to-end quality across our in vivo sample preparation pipeline. Collaborate with technicians, including viral delivery and animal perfusion, tissue processing, and overall readiness for imaging and molecular readouts
- Perform and troubleshoot stereotaxic injections and perfusions as needed to optimize our in vivo sample preparation pipeline and guide protocol improvements
- Routinely evaluate injection and perfusion outcomes (viral labeling, tissue quality, use for downstream work) through microscopy and image analysis
- Define, implement, and maintain sample quality rubrics (e.g. labeling density, barcode density) and ensure samples are scored consistently over time
- Develop and maintain image-based workflows to generate quantitative QC metrics based on partnership and feedback with wet lab and computational staff
- Design and perform experiments to improve sample quality when it is limiting for downstream applications
- Extend quality assessment to RNA integrity and molecular preservation
- Ph.D. in neuroscience, biology, bioengineering, or a related life-science or engineering field, or Ph.D.-equivalent working record
- 35 years of relevant research experience with a strong track record of end-to-end experimental ownership
- Demonstrated hands-on experience with in vivo sample preparation, including stereotaxic injections, perfusions, and tissue handling
- Experience acquiring and working with confocal and widefield microscopy data
- Experience developing or maintaining fit-for-purpose image-analysis workflows (e.g. Python scripts, Fiji macros, or equivalent) to support experimental iteration
- Strong organizational, documentation, and record-keeping practices and strong attention to reproducibility
- Excellent communication and collaboration skills, particularly across wet-lab, imaging, and computational teams
- Experience designing or applying quality control rubrics or scoring systems for biological samples or imaging data
- Familiarity with image-analysis pipelines for cell counting, morphology, spatial distributions, or intensity-based metrics
- Experience working in highly iterative or startup-like research environments and in work where roles span multiple technical domains
- An opportunity to help change the world and work with a world-class interdisciplinary team of scientists and engineers on a field-defining moonshot
- Excellent medical, dental, and vision insurance through a PPO plan; parental leave.
- Generous time off + paid holidays.
- 401K matching up to 6% of base salary
- Ample healthy and energizing food including daily lunches.
- Stipend for fitness and wellness activities.
Base salary range: 96k - 144k
Bonus: Performance-based, up to 20% of base salary
401k match: up to 6% of base salary
Total potential compensation range: 121k - 181k
E11 Bio, LLC is an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other basis protected by applicable local, state, or federal laws or prohibited by Company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.
$96,000 - $144,000 a year
Scan to Apply
Just scan this QR code to apply from your phone.
Job Location
Alameda, California, 94501, United States
Frequently asked questions about this position
Latest Job Openings in California
Public Works Construction Inspector
4LEAF, Inc
Santa Cruz County, CA
Surgery Coordinator/Counselor - Full time
Ramin Tayami MD Inc
Laguna Hills, CA
Medi-Cal and Covered California Enrollment Supervisor
TrueCare
San Marcos, CA
Maintenance Technician
NALS Apartment Homes
Fairfield, CA
Direct Support Professional
Lynn & Darla, LLC
Napa, CA
Continue to apply
Enter your email to continue. You’ll be redirected to the employer’s application.By clicking Continue, you understand and agree to JobTarget's Terms of Service and Privacy Policy.
Apply Now