Director, Clinical Program & Alliance Management at Marengo Therapeutics Inc – Cambridge, Massachusetts

Marengo is seeking a Director of Clinical Program & Alliance Management to lead the operational, strategic, and partner-facing dimensions of its advancing clinical portfolio. This is a high-impact role responsible for steering clinical program execution, driving cross-functional alignment, and ensuring high-quality governance and communication with external partners.

The ideal candidate combines excellence in clinical program leadership, fluency in scientific and operational details, and the professional polish required to represent Marengo in critical external collaborations. This role is well-suited for a strategic operator who thrives in fast-moving environments and enjoys shaping structure, clarity, and partnership excellence within a growing clinical organization.

Company Overview

Marengo Therapeutics is a Phase 2 clinical-stage immuno-oncology company developing first-in-class immune activators designed to precisely stimulate and expand anti-tumor T cells to drive deep, durable anti-tumor immunity. The company has a rich pipeline of multi-specific therapeutics powered by three different platforms supported by advanced antibody discovery and immunology insights. The company’s lead STAR program is progressing in the clinic across multiple solid tumor indications

Marengo’s scientific platform and development strategy are further validated through multiple strategic partnerships with large-cap global pharmaceutical companies, reflecting the industry’s confidence in the novelty and potential impact of Marengo’s approach.

Key Responsibilities

Clinical Program Leadership & Financial Oversight

• Lead day-to-day program operations across one or more clinical-stage assets, ensuring strong execution, risk management, and cross-functional alignment.
• Financial Ownership: Own clinical program budgets and forecasts.
• Strategic Reviews: Facilitate the budget approval process and participate actively in portfolio and quarterly business reviews.
• Build, maintain, and evolve program plans, timelines, milestones, dependencies, and decision logs, ensuring transparency and operational rigor.
• Coordinate clinical development, regulatory, CMC, translational, and biomarker stakeholders to keep the program moving predictably and efficiently.
• Surface risks and bottlenecks early; drive mitigation planning and scenario evaluations for leadership decision-making.
• Facilitate recurring program meetings, ensure accountable follow-ups, and maintain high-quality documentation.

Alliance Management & External Partnering

• Act as the primary operational interface for key external collaborators, CRO partners, and strategic alliances supporting Marengo’s clinical programs.
• Maintain a structured governance framework, including meeting cadence, agenda development, minutes, action tracking, and escalation pathways.
• Ensure consistent, professional, solutions-oriented engagement that reflects Marengo’s science, values, and communication standards.
• Prepare external-ready material,s including scientific summaries, data updates, briefing documents, and meeting outputs for partner interactions.
• Support leadership in high-stakes communications with external stakeholders by synthesizing inputs into clear, concise, decision-ready materials.

Cross-Functional Strategic Support

• Translate complex scientific and clinical updates into accessible, accurate, and compelling content for internal/external audiences.
• Produce high-quality program narratives, portfolio updates, and communications for senior leadership and Board-level visibility.
• Strengthen cross-functional interfaces across research, preclinical, translational, and clinical teams to support smooth program progression.
• Bring structure to evolving processes in a scaling organization; help define operational best practices across the clinical portfolio.

Qualifications

Required

• Experience: 8–12+ years of biotech/pharma experience, specifically featuring roles in Project/Program Management and/or Alliance Management.
• Demonstrated ability to lead clinical program operations, including planning, risk management, and cross-functional coordination.
• Experience managing external collaborations, CRO relationships, or strategic alliances in a clinical-stage environment.
• Strong scientific literacy; able to rapidly understand new biology and clinical data.
• Exceptional written and verbal communication skills, including the ability to synthesize complexity into crisp, decision-grade materials.
• High ownership, maturity, and ability to operate effectively in fast-paced, high-expectation environments.

Preferred

• Advanced scientific degree (PhD, MS) or equivalent scientific depth.
• Experience in immuno-oncology or biologics development.
• Familiarity with partner-governance structures, data-driven external reporting, and joint program management.
• Exposure to vendor management and CRO oversight.
• Ability to influence without authority and build trust across diverse internal and external stakeholders.

Who You Are

• A strategic and operationally disciplined leader who thrives in ambiguity.
• Confident, calm, and professional in partner-facing interactions.
• Highly organized with strong follow-through and attention to detail.
• Motivated by impact, scientific purpose, and the opportunity to shape a growing clinical organization.

Working Model

This role is based in Cambridge, MA, with hybrid flexibility. On-site presence is prioritized for onboarding and key collaboration moments. Marengo values outcomes, accountability, and an environment where high performers thrive.