Director, Translational Immunology in United States at Jobgether

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Director, Translational Immunology based in the United States.

This is a unique opportunity for an accomplished scientific leader to drive translational and nonclinical strategies within innovative rare disease development programs. The role combines deep immunology expertise with cross-functional leadership, supporting the advancement of clinical-stage assets while shaping future therapeutic opportunities. Working in a collaborative and fast-paced research environment, you will partner with experts across clinical development, regulatory affairs, biometrics, medical affairs, and external scientific networks. You will play a critical role in connecting mechanistic biology to clinical outcomes, advancing biomarker strategies, and influencing key development decisions. This position offers significant scientific visibility, leadership responsibility, and the opportunity to contribute directly to therapies that address serious unmet medical needs.

• Serve as the immunology lead for a late-stage clinical development program, providing scientific guidance and strategic direction across translational and nonclinical activities.
• Develop and execute translational research strategies that connect mechanism of action, target engagement, pharmacodynamic responses, and clinical outcomes.
• Design, implement, and interpret biomarker strategies, including mechanistic, predictive, pharmacodynamic, and response biomarkers.
• Collaborate with multidisciplinary teams to support development planning, program governance, scientific decision-making, and portfolio strategy.
• Evaluate emerging scientific, clinical, and competitive developments to inform program priorities and future therapeutic opportunities.
• Contribute to the identification and assessment of new indications and expansion opportunities within rare and immune-mediated diseases.
• Support regulatory activities by contributing to submissions, briefing documents, investigator brochures, and interactions with health authorities.
• Interpret pharmacology, toxicology, translational, and clinical data to support development objectives and regulatory requirements.
• Lead scientific collaborations with CROs, academic institutions, consultants, key opinion leaders, and external research partners.
• Oversee externally conducted mechanistic and translational studies while ensuring scientific rigor and alignment with development goals.
• Represent programs at scientific conferences, external meetings, and collaborative research initiatives.
• Mentor colleagues, strengthen organizational immunology capabilities, and foster a culture of scientific excellence, innovation, and collaboration.
• Serve as an internal subject matter expert in immunology, B-cell biology, immune signaling, and disease mechanisms relevant to therapeutic development.

• Bachelor’s degree in Life Sciences or a related scientific discipline required.
• PhD, MD, PharmD, or equivalent advanced degree in Immunology, Cell Biology, Molecular Biology, Pharmacology, or a related field preferred.
• Minimum of 10 years of relevant biopharmaceutical industry experience, or at least 6 years with an advanced scientific degree.
• Deep expertise in immunology, including strong knowledge of B-cell biology, adaptive immunity, innate immune signaling, and immune-mediated diseases.
• Proven experience supporting clinical-stage drug development programs and translating mechanistic biology into clinical development strategies.
• Demonstrated success leading translational science initiatives and biomarker development programs.
• Experience managing externally conducted research through CROs, academic collaborators, and scientific consultants.
• Strong understanding of regulatory requirements supporting nonclinical and clinical development activities.
• Experience contributing to regulatory submissions, briefing documents, investigator brochures, and related development documentation.
• Ability to work effectively within highly matrixed, cross-functional organizations and influence decision-making at multiple levels.
• Strong project leadership, organizational, analytical, and problem-solving capabilities.
• Excellent communication, presentation, stakeholder management, and scientific storytelling skills.
• Experience in autoimmune diseases, inflammatory diseases, nephrology, rare diseases, or related therapeutic areas is highly desirable.
• Familiarity with kidney disease biology, glomerular disorders, proteinuric diseases, podocytopathies, or renal injury mechanisms is advantageous.
• Demonstrated ability to integrate complex scientific datasets and generate actionable insights that guide development strategy.
• Commitment to scientific excellence, innovation, collaboration, and improving outcomes for patients with serious diseases.
• Ability to participate in periodic onsite collaboration and face-to-face work activities as required.

• Competitive base salary ranging from $189,000 to $246,000 annually, based on experience, qualifications, and location.
• Annual short-term incentive opportunities tied to individual and organizational performance.
• Long-term incentive compensation, including company equity or stock-based awards.
• Comprehensive medical, dental, and vision healthcare coverage for eligible employees and dependents.
• Life insurance and disability protection programs.
• Retirement savings plan with employer matching contributions.
• Generous paid time off and holiday programs.
• Wellness initiatives, employee assistance resources, and well-being support programs.
• Flexible work arrangements with remote work opportunities and collaborative onsite engagement.
• Career growth opportunities within an innovative, science-driven organization focused on advancing therapies for rare diseases.
• Access to a collaborative environment that values scientific leadership, professional development, and continuous learning.