Scientist I, Analytical Development in Charlestown, Massachusetts at Solid Biosciences
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Job Description
Scientist I, Analytical Development – Solid Biosciences
Charlestown, MA
Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care.
Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases.
We are looking for an experienced Scientist I to support the Analytical Development team. This individual would be responsible for analytical cell-based assay development, qualification, and operational support for Solid’s (pre)clinical portfolio. This role will focus specifically on cell-based analytical assay development (with various read-out) and is expected to independently drive assay development with limited oversight.
Reporting to the Senior Scientist, Analytical Development, this is an on-site position based out of Solid’s headquarters in Charlestown, MA.
Responsibilities
- Drive the design and implementation of cell-based and functional potency assays to support the Solid Biosciences gene therapy portfolio.
- Support the development and execution of cell-based assays aligned with process development and cGMP manufacturing of Solid Biosciences’ lead candidates.
- Contribute to laboratory operations, including routine and non-routine analytical testing, and coordinate activities with internal Process Development and Vector Core Manufacturing teams.
- Author and review SOPs, technical reports, and regulatory documents to support development programs and submissions.
- Manage laboratory equipment and inventory, and compile, analyze, and present data to support process development and cross-functional teams.
- Maintain accurate and well-documented analytical records, including electronic laboratory notebooks.
- Mentor, and train junior scientists in cell-based analytical method development as needed.
- Perform additional duties and contribute to ad hoc projects as required.
Required Qualifications
- PhD in cell biology, biotechnology, or relevant field with 0-2+ years of relevant industry experience.
- Or: MS with 4-6+ years of relevant experience.
- Excellent communication, technical, and organizational skills are required.
- Must be a team player and embrace an interactive team-based culture.
- Strong understanding of basic cell biology, cellular pathways, and cell growth parameters.
- Extensive hands-on experience in mammalian cell culture, cell line characterization, cell-based assay development, and cell banking required.
- Proven ability to develop cell-based potency assays in an industrial environment, including MOA based assay design, development, implementation, and qualification using ICH Q2 guidelines.
- Extensive experience with plate-based readouts (including ELISA, MSD and ICW)
- Hands-on experience with relevant analytical / statistical software suites, e.g. PLA, JMP, Softmax Pro.
- Self-motivator driven to deliver quality results within project timelines
- Proven troubleshooting, problem solving and investigational skills.
- Experience in developing potency assays and analysis of AAV or similar viral vectors preferred.
- Familiar with Solid’s disease areas of interest (DMD, FA, CPVT, etc.) is preferred.
Compensation
The base compensation range for this role is: $125,000 – $140,000
Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance.
Benefits and Solid Advantages
At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices.
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