Scientist / Senior Scientist, Chemical Biology in San Diego, California at Vividion Therapeutics, Inc

*Note: exact level depending on experience*

Company Overview:

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.

We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.

Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025.

Job Summary:

The successful candidate will have extensive hands-on experience and expertise in the evaluation of the impact of small molecules on protein function and stability both in vitro and in a cellular context via cell and/or biochemical assay development. This position will be responsible for leading/supporting efforts towards the validation of novel drug targets via multiple mechanisms, including testing the effects of tool compounds on proteins in cellular and biochemical settings, and the use of Vividion’s proprietary chemical proteomics platform.

Education and Experience requirements:

• PhD and post-doc experience in biochemistry, chemical biology, cell biology or related disciplines
• 5+ years of post-graduate industry experience in chemistry, chemical biology or pharmaceutical chemistry
• Required technical skills include a strong molecular biology skill set (e.g., DNA cloning, site-directed mutagenesis, CRISPR, transient transfection, viral transduction, gene expression analysis), Protein expression analysis (western blot/ ELISA/ProteinSimple), mammalian cell culture, microscopy, and functional/phenotypic assays (Cell Viability 2D and 3D, Soft agar, Apoptosis)
• Experience in mass spectrometry-based analyses for chemical proteomics investigations along with chemical principles and structure-activity relationships
• Deep understanding of protein/ligand interactions, how to measure them, and how to characterize downstream functional effects arising from those interactions

Required Key Attributes:

• Candidates must have strong communication skills as evidenced in public presentations and/or peer reviewed literature.
• Candidates must have effective troubleshooting and problem-solving skills.
• Candidates must be an effective team player, strong individual contributor, flexible, and able to handle multiple tasks and deliver high quality results under tight timelines.

Pay & Benefits:

The anticipated base salary for this position ranges from $120,000 to $155,000 depending on relevant skills, competencies, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.

EEO & Employment Eligibility:

Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other characteristic protected by applicable federal, state, or local laws.

Privacy Policy:

The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/publication/privacy-noticeforcalifornia-candidates/.