Pr. Associate Scientist/Scientist I, Analytical Development in Charlestown, Massachusetts at Solid Biosciences
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Job Description
Principal Associate Scientist/Scientist I, Analytical Development (Molecular Biology) – Solid Biosciences
Charlestown, MA
Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care.
Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases.
We are looking for an experienced Principal Associate Scientist/Scientist I to support the Analytical Development Molecular Biology team. This individual would be responsible for molecular assay development, qualification, and operational support for Solid’s (pre)clinical portfolio. This role is expected to independently drive assay development with limited oversight.
Reporting to the Senior Scientist, Analytical Development, this is an on-site position based out of Solid’s headquarters in Charlestown, MA.
Key Position Responsibilities
- Provide technical expertise on different aspects of analytical development, including identifying new technologies, assessing Critical Quality Attributes (CQAs), process-related and product-related impurities, and executing methods for characterization of final drug substance/ product (DS/DP).
- Develop, optimize, and qualify molecular characterization methods to support the Solid Biosciences gene therapy portfolio.
- Perform and coordinate routine and non-routine analytical testing in support of internal Process Development and Vector Core teams as well as cGMP product characterization.
- Provide analytical support to QC/CMOs/CTOs not limited to technology transfer, method feasibility, optimization, qualification, troubleshooting, data trending, document review, and reporting.
- Compile, analyze, and present data findings to cross functional teams and senior leadership.
- Author and review SOPs, development reports, and documents to support regulatory submissions.
- Manage laboratory equipment and critical reagents inventory.
- Maintain accurate and well-documented analytical records including electronic laboratory notebooks (ELN).
- Mentor and train junior scientists and/or new team members.
- Perform additional duties and contribute to ad hoc projects as required.
Requirements
- Bachelor’s degree in Molecular Biology, Biochemistry, Genetics or related field and 6-8+ years’ experience in analytical development within a biotech/pharmaceutical and/or Quality Control environment required or MS with 4-6+ years of experience or Ph.D. with 0-2+ years of experience.
- Deep expertise in molecular biology complemented by extensive hands-on experience in long-read next generation sequencing (NGS) workflows, integrating wet-lab execution with analysis and interpretation of complex sequencing datasets.
- In-depth understanding of molecular techniques such as qPCR, ddPCR, and ELISA.
- Proficiency working with viral vectors especially AAV.
- Familiarity with relevant analytical / statistical software suites, not limited to Benchling, QX Manager, AccuSEQ, GraphPad Prism, and Softmax Pro.
- Good understanding of GxP compliance including regulatory requirements and trends related to product quality.
- Excellent critical thinking, technical, communication, and organizational skills required.
- Must be a team player willing to embrace an interactive team-based culture.
Compensation
The base compensation range for this role is: $110,000.00 - $135,000.00
Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance.
Benefits and Solid Advantages
At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices.
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