Senior Medical Director, Early Clinical Development in United States at Jobgether

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Senior Medical Director, Early Clinical Development based in the United States.

This is a high-impact clinical leadership role at the forefront of early-stage drug development for genetically defined rare diseases. You will shape and execute clinical development strategies from first-in-human studies through proof-of-concept, directly influencing critical go/no-go decisions across innovative therapeutic programs. Working in a highly cross-functional environment, you will collaborate with experts in translational science, clinical pharmacology, biomarkers, safety, and regulatory affairs to design and deliver high-quality early clinical studies. The role requires strong scientific judgment, strategic thinking, and the ability to translate complex data into clear development decisions. You will also contribute to portfolio-level strategy, support evaluation of new opportunities, and provide leadership within a highly specialized R&D organization. This position combines hands-on clinical oversight with broader strategic influence across an early development pipeline.

This role is responsible for leading early clinical development strategy and execution across multiple therapeutic assets, ensuring strong scientific rigor and clear decision-making throughout first-in-human and proof-of-concept stages. You will act as a key clinical leader guiding programs through high-risk development phases while shaping broader portfolio direction.

• Develop and lead early clinical development strategies and integrated clinical development plans from first-in-human through proof-of-concept studies
• Serve as Clinical Development Team Leader across assigned assets, driving cross-functional alignment and strategic execution
• Design and oversee Phase 1 and Phase 2 clinical studies, ensuring high-quality data generation for development decisions
• Contribute to regulatory submissions including pre-IND, IND, and other early-stage filings
• Partner with translational science, biomarkers, clinical pharmacology, and safety teams to design robust clinical and biomarker strategies
• Lead interpretation of emerging clinical data to guide safety, efficacy, and benefit-risk decisions
• Support natural history study design to improve patient characterization and endpoint development
• Provide mentorship and matrix leadership within the early clinical development organization
• Contribute to portfolio evaluation, governance discussions, and external business development assessments

The ideal candidate is an experienced clinical development leader with deep expertise in early-phase clinical research, translational science, and rare disease drug development. You bring strong scientific leadership, cross-functional collaboration skills, and the ability to operate in complex, data-driven environments.

• Medical degree (MD or equivalent) with board certification or relevant clinical training
• Extensive experience in clinical development, with strong focus on early-phase (Phase 1/2) trials
• Proven track record in translational clinical research, ideally within biotech or pharmaceutical environments
• Strong expertise in study design, clinical strategy, and interpretation of complex clinical data
• Experience working with biomarkers, pharmacology, and regulatory submission processes
• Demonstrated leadership in cross-functional teams and ability to influence senior stakeholders
• Experience in rare diseases or genetically defined conditions strongly preferred
• Strong communication skills, with ability to engage scientific experts and regulatory authorities
• Strategic thinker with strong decision-making and benefit-risk assessment capabilities

• Competitive base salary aligned with experience and market benchmarks
• Annual performance-based incentive compensation
• Comprehensive medical, dental, and vision insurance coverage
• Retirement savings plan with company contributions
• Generous paid time off, including vacation, holidays, and sick leave
• Professional development and scientific leadership opportunities
• Participation in a highly innovative, research-driven biotech environment focused on rare diseases
• Collaborative and mission-driven culture centered on patient impact