Scientist II, Cell Pharmacology in Watertown, Massachusetts at C4 Therapeutics Inc
Job Description
About C4 Therapeutics:
C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transform patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com.
Job Summary
C4 Therapeutics is seeking a scientifically motivated Research Scientist II to join the Cell Pharmacology group within Lead Discovery. In this hands-on role, you will develop and execute robust cell-based assays to inform screening, compound profiling, structure–activity relationships, and discovery program progression in targeted protein degradation. Working closely with colleagues across Lead Discovery, Biology, Medicinal Chemistry, and other functions, you will tackle challenging scientific questions and translate rigorous experimentation into program decisions. The role offers scientific ownership, access to advanced technologies, and opportunities to expand your technical and drug discovery expertise in a collaborative environment that values independence, curiosity, open communication, and diverse perspectives—all while helping advance medicines with the potential to transform patients’ lives.
Your Role
- Develop, optimize, validate, and execute fit-for-purpose cell-based assays for screening, hit confirmation, compound profiling, mechanism-of-action studies, and SAR progression.
- Apply HiBiT, HTRF, and CellTiter-Glo technologies to measure protein degradation, pathway modulation, viability, and related pharmacology endpoints.
- Independently culture, characterize, bank, and troubleshoot mammalian cell lines; engineer cellular models using stable or transient expression and genome-editing approaches.
- Plan rigorous experiments with appropriate controls and performance criteria; identify and resolve assay and cell-line issues.
- Process, analyze, visualize, interpret, and document screening and pharmacology data; translate findings into recommendations for compound and project decisions.
- Proactively communicate data, progress, risks, and next steps through timely updates, presentations, and cross-functional discussions.
- Maintain accurate experimental records and contribute to laboratory safety, organization, reagent stewardship, technology evaluation, and continuous improvement.
- As needed, support CRO activities including assay transfer, protocol review, troubleshooting, timeline coordination, and data-quality assessment.
Your Background
Required:
- A PhD in cell biology, molecular biology, cancer biology, pharmacology, biotechnology, or a related discipline, with at least two years of relevant post-PhD research experience or a Master’s Degree with at least three years of relevant post-graduate experience.
- Expertise developing and executing multi-well cell-based screening and profiling assays; hands-on proficiency with HiBiT, HTRF, and CellTiter-Glo, including optimization, controls, performance assessment, and troubleshooting.
- Experience with medium- or high-throughput workflows, laboratory automation, liquid handling, plate readers, or assay data systems; strong quantitative skills in processing, visualizing, and interpreting cellular assay and screening data.
- Advanced, independent mammalian cell-culture skills across multiple cell lines, including maintenance, expansion, cryopreservation, banking, quality control, and troubleshooting; experience engineering cell lines and establishing fit-for-purpose cellular models.
- Ability to work independently, prioritize multiple deliverables, and adapt in a fast-paced drug discovery environment; excellent collaboration and communication skills, including proactive sharing of data, progress, challenges, and proposed next steps.
Preferred:
- Experience in biotechnology or pharmaceutical industry working in small-molecule drug discovery and targeted protein degradation.
- Experience working with CROs, including assay transfer, study oversight, troubleshooting, and data review.
Compensation
The base pay range for this position at commencement of employment is expected to be between $142,474.00 and $157,472.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.
C4 Therapeutics is an Equal Opportunity Employer.
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