Medical Director/Senior Medical Director, Clinical Development in United States at Jobgether

This position is posted by Jobgether on behalf of a partner company. We are currently looking for a Medical Director/Senior Medical Director, Clinical Development in the United States.

This role is a high-impact clinical leadership position focused on advancing innovative oncology therapies through all stages of clinical development. You will serve as a key medical authority for an AML T-cell engager program, driving clinical strategy, trial design, and execution in a fast-paced, science-driven environment. The position requires close collaboration with cross-functional teams including clinical operations, regulatory affairs, pharmacovigilance, and translational science. You will provide critical medical oversight, ensuring the integrity, safety, and scientific validity of clinical trials while interpreting complex data sets to guide development decisions. Acting with a high degree of independence, you will also contribute to regulatory interactions, scientific communications, and publication strategy. This is a highly visible role ideal for a physician-scientist passionate about transforming cancer treatment through next-generation immunotherapies.

• Serve as medical monitor for assigned clinical trials, providing ongoing oversight of patient safety, study conduct, and clinical integrity.
• Contribute to clinical study design, operational feasibility assessments, and site selection in partnership with cross-functional study teams.
• Review and provide expert input on key clinical documents, including protocols, informed consent forms, safety plans, and monitoring charters.
• Collaborate with Regulatory Affairs on investigator brochures, briefing documents, and other regulatory submissions and communications.
• Lead and support investigator meetings, site initiation visits, and ongoing relationships with clinical trial investigators.
• Partner with clinical, data management, biostatistics, pharmacovigilance, and external partners to ensure high-quality study execution.
• Oversee interpretation of clinical safety and efficacy data, contributing to study conclusions and development strategy.
• Support scientific communication efforts, including abstracts, publications, presentations, and conference participation.

• MD, DO, or equivalent medical degree with board certification or strong clinical background in hematology, oncology, or hematology-oncology.
• 3–5+ years of clinical research experience in biotech, pharma, or academic clinical trial leadership (Senior level requires broader independent program leadership).
• Strong experience in oncology drug development, including clinical trial design, execution, and interpretation of safety/efficacy data.
• Solid understanding of Good Clinical Practice (GCP) and regulatory expectations for oncology clinical development.
• Ability to make independent, timely, and high-quality decisions in a fast-paced biotech environment.
• Excellent communication and interpersonal skills with experience collaborating across multidisciplinary teams.
• Preferred: experience in AML, leukemia, or other myeloid malignancies.
• Preferred: experience with T-cell engagers, bispecific antibodies, or immune effector therapies, including CRS/ICANS management.
• Strong scientific rigor, analytical thinking, and ability to translate data into clinical insight.

• Competitive base salary ranging from $300,000 to $390,000 depending on experience and qualifications.
• Annual performance bonus opportunity of approximately 25% of base salary.
• Annual equity awards, stock options, and employee stock purchase plan.
• Comprehensive medical, dental, vision, life, and disability insurance coverage.
• 401(k) plan with employer match.
• Flexible paid time off, paid holidays, and end-of-year company shutdown.
• Paid parental leave and tuition reimbursement programs.
• Cell phone reimbursement and additional employee support benefits.
• Remote or hybrid flexibility depending on experience and business needs, with occasional travel.